Parvin Mansouri
Tehran university of medical sciences, Iran
Title: Prevalence of liver dysfunction and its related factors in psoriasis patients referred to Imam Khomeini Hospital from 2014-2015
Biography
Biography: Parvin Mansouri
Abstract
Introduction: Psoriasis is an inflammatory disease of the skin. Most studies have shown a higher prevalence of metabolic syndrome (MS) in psoriatic patients. Recent studies show that liver disease especially non-alcoholic fatty liver disease (NAFLD) is also frequent in psoriasis patients.
Aim & Method: We performed a case study on 200 adult psoriasis patients. Liver dysfunction was diagnosed by elevated liver enzymes after excluding other liver diseases.
Results: The occurrence of liver enzyme dysfunction was higher in psoriasis patients than in controls (19 patients; P=0.002). Alcohol and smocking has relation with liver dysfunction (P value=0.004) and also liver dysfunction has relation with drugs therapy in psoriasis patients (P value=0.034).
Conclusion: Patients with liver dysfunction and psoriasis have more severe skin disease and are at higher risk of severe liver fibrosis than patients without psoriasis. Routine work-up for liver dysfunction may be warranted in patients with psoriasis, especially when potentially hepatotoxic drug therapy is being considered.